HORDB

ID: hor002797
Uniprot ID: P07712
Protein name: Proline-rich mature peptide
Gene name: NA
Organism: Aplysia californica (California sea hare)
Family: NA
Source: animal
Expression: Neurons L2-4 and L6, also called giant dorsal LUQ (Left Upper Quadrant) neurons of the abdominal ganglion. Also expressed in smaller neurons in the CNS and in peripheral organs such as the kidney.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: TIPDRLPQTEESSLPDFGFSHLPALPLELFYNPRDLVHSGFRPRLCSVSGVEGYPPCVESHSDRKMKNLLDDLFGL
Length: 76(37-112)
Propeptide: MKTAVLLVCLAYVMAAILSLCASAPSWRPQGRFGKRTIPDRLPQTEESSLPDFGFSHLPALPLELFYNPRDLVHSGFRPRLCSVSGVEGYPPCVESHSDRKMKNLLDDLFGL
Signal peptide: MKTAVLLVCLAYVMAAILSLCAS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002797_AF2.pdb

hor002797_ESM.pdb

Mass:	989362	Formula:	C384H590N102O114S3
Absent amino acids:	W	Common amino acids:	L
pI:	4.98	Basic residues:	10
Polar residues:	21	Hydrophobic residues:	23
Hydrophobicity:	-34.34	Boman Index:	-13105
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	83.29
Instability Index:	4396.71	Extinction Coefficient cystines:	3105
Absorbance 280nm:	41.4

PubMed ID: 7784264
Title: Processing of the L5-67 Precursor Peptide and Characterization of LUQIN in the LUQ Neurons of Aplysia Californica